H2N2V1, Main, Exploration, bibRecord, 000E55

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration▿

Identifieur interne : 000E55 ( Main/Exploration ); précédent : 000E54; suivant : 000E56

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration▿

Auteurs : Shuku Kubo [Japon] ; Takanori Tomozawa [Japon] ; Masayo Kakuta [Japon] ; Akane Tokumitsu [Japon] ; Makoto Yamashita [Japon]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2010.

RBID : PMC:2825999

Abstract

Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for use for the treatment and prophylaxis of influenza. We have reported on laninamivir (code name, R-125489), a novel neuraminidase inhibitor, and have discovered that the laninamivir prodrug CS-8958 worked as a long-acting neuraminidase inhibitor in a mouse influenza virus infection model when it is intranasally administered. In this study, CS-8958 was administered just once 7 days before infection and showed significant efficacy in vivo. The efficacy of a single administration of CS-8958 after viral infection was then compared with that of repeated administrations of oseltamivir phosphate or zanamivir in mice and ferrets. CS-8958 showed efficacy superior or similar to the efficacies of the two licensed NA inhibitors. CS-8958 also significantly reduced the titers of an oseltamivir-resistant H1N1 virus with a neuraminidase H274Y substitution in a mouse infection model. These results suggest that since CS-8958 is characteristically long lasting in the lungs, it may be ideal for the prophylaxis and treatment of influenza.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825999

DOI: 10.1128/AAC.01311-09
PubMed: 20047917
PubMed Central: 2825999

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration<xref ref-type="fn" rid="fn2">▿</xref>
 </title>
<author><name sortKey="Kubo, Shuku" sort="Kubo, Shuku" uniqKey="Kubo S" first="Shuku" last="Kubo">Shuku Kubo</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomozawa, Takanori" sort="Tomozawa, Takanori" uniqKey="Tomozawa T" first="Takanori" last="Tomozawa">Takanori Tomozawa</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kakuta, Masayo" sort="Kakuta, Masayo" uniqKey="Kakuta M" first="Masayo" last="Kakuta">Masayo Kakuta</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tokumitsu, Akane" sort="Tokumitsu, Akane" uniqKey="Tokumitsu A" first="Akane" last="Tokumitsu">Akane Tokumitsu</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamashita, Makoto" sort="Yamashita, Makoto" uniqKey="Yamashita M" first="Makoto" last="Yamashita">Makoto Yamashita</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20047917</idno>
<idno type="pmc">2825999</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825999</idno>
<idno type="RBID">PMC:2825999</idno>
<idno type="doi">10.1128/AAC.01311-09</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000608</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000608</idno>
<idno type="wicri:Area/Pmc/Curation">000608</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000608</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000926</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000926</idno>
<idno type="wicri:Area/Ncbi/Merge">000468</idno>
<idno type="wicri:Area/Ncbi/Curation">000468</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000468</idno>
<idno type="wicri:doubleKey">0066-4804:2010:Kubo S:laninamivir:prodrug:cs</idno>
<idno type="wicri:Area/Main/Merge">000E61</idno>
<idno type="wicri:Area/Main/Curation">000E55</idno>
<idno type="wicri:Area/Main/Exploration">000E55</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration<xref ref-type="fn" rid="fn2">▿</xref>
 </title>
<author><name sortKey="Kubo, Shuku" sort="Kubo, Shuku" uniqKey="Kubo S" first="Shuku" last="Kubo">Shuku Kubo</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomozawa, Takanori" sort="Tomozawa, Takanori" uniqKey="Tomozawa T" first="Takanori" last="Tomozawa">Takanori Tomozawa</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kakuta, Masayo" sort="Kakuta, Masayo" uniqKey="Kakuta M" first="Masayo" last="Kakuta">Masayo Kakuta</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tokumitsu, Akane" sort="Tokumitsu, Akane" uniqKey="Tokumitsu A" first="Akane" last="Tokumitsu">Akane Tokumitsu</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yamashita, Makoto" sort="Yamashita, Makoto" uniqKey="Yamashita M" first="Makoto" last="Yamashita">Makoto Yamashita</name>
<affiliation wicri:level="1"><nlm:aff id="aff0">Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
<idno type="eISSN">1098-6596</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for use for the treatment and prophylaxis of influenza. We have reported on laninamivir (code name, R-125489), a novel neuraminidase inhibitor, and have discovered that the laninamivir prodrug CS-8958 worked as a long-acting neuraminidase inhibitor in a mouse influenza virus infection model when it is intranasally administered. In this study, CS-8958 was administered just once 7 days before infection and showed significant efficacy <italic>in vivo</italic>
. The efficacy of a single administration of CS-8958 after viral infection was then compared with that of repeated administrations of oseltamivir phosphate or zanamivir in mice and ferrets. CS-8958 showed efficacy superior or similar to the efficacies of the two licensed NA inhibitors. CS-8958 also significantly reduced the titers of an oseltamivir-resistant H1N1 virus with a neuraminidase H274Y substitution in a mouse infection model. These results suggest that since CS-8958 is characteristically long lasting in the lungs, it may be ideal for the prophylaxis and treatment of influenza.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Kubo, Shuku" sort="Kubo, Shuku" uniqKey="Kubo S" first="Shuku" last="Kubo">Shuku Kubo</name>
</region>
<name sortKey="Kakuta, Masayo" sort="Kakuta, Masayo" uniqKey="Kakuta M" first="Masayo" last="Kakuta">Masayo Kakuta</name>
<name sortKey="Tokumitsu, Akane" sort="Tokumitsu, Akane" uniqKey="Tokumitsu A" first="Akane" last="Tokumitsu">Akane Tokumitsu</name>
<name sortKey="Tomozawa, Takanori" sort="Tomozawa, Takanori" uniqKey="Tomozawa T" first="Takanori" last="Tomozawa">Takanori Tomozawa</name>
<name sortKey="Yamashita, Makoto" sort="Yamashita, Makoto" uniqKey="Yamashita M" first="Makoto" last="Yamashita">Makoto Yamashita</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E55 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E55 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2825999
   |texte=   Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration▿ 
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:20047917" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration▿

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration▿

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.